Histopathological landscape of rare oesophageal neoplasms

Figure 1 Representative rare histotypes of oesophageal neoplastic lesions. A: Neuroendocrine carcinoma with full-thickness oesophageal wall involvement; at higher magnification, note the organoid growth pattern of the lesion; B: A case of primitive oesophageal melanoma with melanin deposits; C: Granular cell tumour of the oesophageal wall; note the sheets or nests of plump, round or polygonal cells with eosinophilic granular cytoplasm at higher magnification; D: Oesophageal gastrointestinal stromal tumour. E: Inflammatory myofibroblastic tumour characterized by spindled myofibroblasts and ganglion-like cells dispersed in a myxoid background with a lymphocytic, plasma cellular and eosinophilic infiltrate. F: Oesophageal lipoma; G: High-power field of an atypical oesophageal lipomatous tumour (i.e., ”well-differentiated liposarcoma”) (arrowhead showing a lipoblast).

Figure 2 Representative endoscopic and radiologic features of rare histotypes of oesophageal neoplastic lesions. A: Endoscopic appearance of a submucosal oesophageal lipoma; B: A protuberant oesophageal schwannoma is evident at endoscopy; C: Computed tomography scan showing an oesophageal gastrointestinal stromal tumour (3.5 cm of diameter) located at the inferior third of the oesophageal wall.