Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency: A case report

Figure 1 Histology and blood leukocyte cytokine profile of patient with cytosolic isoleucyl-tRNA synthetase deficiency. A: Liver histology showing hydropic change, but no classic apoptosis of the hepatocytes; B: Pancolitis, with diffuse increase in inflammatory cells, cryptitis and crypt abscess formation. High power insert: A few apoptotic epithelial cells seen, but within normal limits, c/cytokine profile; C: Cytokine secretion from peripheral blood leukocytes of patient with isoleucyl-tRNA synthetase deficiency compared with healthy donor. HD: Healthy donor; IARS: Isoleucyl-tRNA synthetase.