Mini-invasive vs open resection of colorectal cancer and liver metastases: A meta-analysis

Figure 1 Flow chart of the study search strategies. CRC: Colorectal cancer; SCRLM: Synchronous colorectal liver metastases.

Figure 2 Forest plots of the meta-analysis for intraoperative outcomes. A: The operative time was compared between the minimally invasive surgery (MIS) and open surgery (OS) groups; B: Intraoperative estimated blood loss was compared between the MIS and OS groups; C: Number of intraoperative blood transfusions was compared between the MIS and OS groups; D: Time to bowel functional recovery was compared between the MIS and OS groups; E: Time to start diet was compared between the MIS and OS groups; F: Length of postoperative hospital stay was compared between the MIS and OS groups. MIS: Minimally invasive surgery; OS: Open surgery; CI: Confidence interval; SD: Standard deviation.

Figure 3 Forest plots of the meta-analysis for complications. A: Overall complications were compared between the minimally invasive surgery (MIS) and open surgery (OS) groups; B: Severe (Clavien–Dindo grade ≥ 3) complications were compared between the MIS and OS groups; C: Surgical complications were compared between the MIS and OS groups; D: General complications were compared between the MIS and OS groups. MIS: Minimally invasive surgery; OS: Open surgery; CI: Confidence interval.

Figure 4 Forest plots of the meta-analysis for long-term outcomes. A: The overall survival was compared between the minimally invasive surgery (MIS) and open surgery (OS) groups; B: Disease-free survival was compared between the MIS and OS groups. MIS: Minimally invasive surgery; OS: Open surgery; CI: Confidence interval; SE: Standard error.

Figure 5 Funnel plots of the number of intraoperative blood transfusions and postoperative complications in patients between the minimally invasive surgery and open surgery groups. A: Intraoperative blood transfusions; B: Postoperative complications. RR: Relative risk.