Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease

Figure 1 Schematic diagram of the Th17 cell differentiation pathway. APC: Antigen-presenting cells; TGF-β: transforming growth factor β; IL: Interleukin; IL-23R: Interleukin-23 receptor 1.

Figure 2 Fluorescence detected in cells transfected with the recombinant or empty vector. Allele G and allele A indicate the fluorescence results of cells transfected with the pGL3-rs2227473_G and pGL3-rs2227473_A plasmids, respectively. F/R: Firefly/renilla luciferase values; ^aP < 0.05.

Figure 3 Immunohistochemical staining for interleukin-22 receptor 1 in intestinal biopsy tissues. A: Colon polyps; B: Colon cancer; C: Crohn's disease; D: Intestinal tuberculosis. Magnification, 100×.

Figure 4 In typical caseous necrotic granulomas, Langhans giant cells with high interleukin-22 receptor 1 expression are present at the edge of granulomas.

Figure 5 Total integrated optical density/total area of immunohistochemical images. IOD: Integrated optical density; CD: Crohn's disease; ITB: Intestinal tuberculosis; ^aP < 0.05, ^bP < 0.01.