Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection

Figure 1 IRF5 linkage disequilibrium maps. Pairwise r² between 4 polymorphisms in the IRF5 locus in the 3’ UTR region in Vietnamese hepatitis B virus infected patients (A) and in healthy controls (B) are presented. The color scale from white to dark indicates r² values from 0 to 1. The blocks of grey and dark grey represent SNPs that are all in high linkage disequilibrium with each other.

Figure 2 Association of IRF5 haplotypes with clinical parameters in hepatitis B virus patients. Box-plots illustrate median values with 25 and 75 percentiles with whiskers to 10 and 90 percentiles; the distribution of IRF5 haplotypes to liver enzymes, bilirubin and hepatitis B virus viral load was executed using pairwise permutation tests. Adjusted P values are presented under the false discovery rate correction method applied for multiple comparisons. NS: Not significant; AST and ALT: Aspartate and alanine amino transferase.