Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression

Figure 1 Pooled incidence and distribution of preexisting primary and secondary reverse transcriptase mutations compiled using data from 50 previous studies. The distribution and overall incidence of RT region is presented; numbers indicate the pooled incidence rate of the RT mutation in a total of 8,435 treatment-naïve patients. ^aPre-existing RT mutation associated with the progression of HCC in treatment-naïve patients.

Figure 2 Pooled incidence and distribution of preexisting putative and pretreatment reverse transcriptase mutations compiled using data from 50 previous studies. The distribution and overall incidence of RT region is presented; numbers indicate the pooled incidence rate of the RT mutation in a total of 8435 treatment-naïve patients. ^aPre-existing RT mutation associated with the progression of HCC in treatment-naïve patients; ^bA-B interdomain region.

Figure 3 Schematic representation indicating the role of preexisting hepatitis B virus reverse transcriptase mutations in liver disease progression and treatment outcomes. HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; ASC: Asymptomatic carriers; CHB: Chronic hepatitis B; HIV: Human immunodeficiency virus.