Nonalcoholic fatty liver disease and liver transplantation - Where do we stand?

Figure 1 Higher incidence of metabolic syndrome and its complications leads to a higher incidence of nonalcoholic steatohepatitis/nonalcoholic fatty liver disease and, consequently, to more patients who have end-stage liver disease. At the same time, due to MetS and its components, we will have more steatotic livers, i.e., more organs of lower quality that are available for LT. Therefore, in the future, since NAFLD will affect both the demand for LT and the supply of available organs. Patients who have NASH and are candidates for LT have several comorbidities and are unique LT candidates. Post-LT, there are several challenging issues for NAFLD: recurrent NAFLD, de novo NAFLD and the risk for CVD and CKD. MetS: Metabolic syndrome; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; ESLD: End-stage liver disease; LT: Liver transplantation; CVD: Cardiovascular diseases; CKD: Chronic kidney disease.