Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture

Figure 1 Underlying etiologies of patients with clear diagnoses in histopathological reports. IgG4-RD: IgG4-related disease; PSC: Primary sclerosing cholangitis; PBC: Primary biliary cirrhosis.

Figure 2 Study design. AIH: Autoimmune hepatitis; Eos: Eosinophilic granulocytes; HPF: High power field; PSC: Primary sclerosing cholangitis; PBC: Primary biliary cirrhosis.

Figure 3 Infiltration of eosinophilic granulocytes and IgG4 positive plasma cells of patients with eosinophilic cholangitis without IgG4 positive plasma cells (A and B); as well as patients with IgG4-related cholangitis with eosinophilic infiltration (C and D); and without eosinophilic infiltration (E and F). A, C and E: × 200, hematoxylin-eosin; B, D and F: × 200, IgG4-Ab.