Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery

Figure 1 Alterations in disseminated intravascular coagulopathy-associated parameters between before and after 1 wk of treatment with thrombomodulin-α. Disseminated intravascular coagulopathy (DIC) scores [Japanese Association for Acute Medicine (JAAM)], systemic inflammatory response syndrome (SIRS) scores, quick-sequential organ failure assessment (qSOFA) scores, platelet (PLT) counts, prothrombin time (PT) ratios, and fibrin degradation products (FDP) values were compared for before and after 1 wk of thrombomodulin-α (TM-α) treatment. All parameters, except for FDP values, were significantly improved by TM-α administration after 1 wk. The Mann-Whitney U-test was used for the analysis.

Figure 2 Survival analysis of the disseminated intravascular coagulopathy patients treated with thrombomodulin-α. Overall survival at 28 d was examined using the Kaplan-Meier method (n = 31) in order to evaluate the efficacy of thrombomodulin-α (TM-α) administration. The patients used in this analysis were treated with TM-α more than 1 d, and the overall survival rate was 71%.