Genetic biomarkers for hepatocellular cancer risk in a caucasian population

Figure 1 Classification and regression tree representation of the markers combination significantly predictive of hepatocellular carcinoma risk. Fractions indicate the number of HCC cases patients vs number of HBV/HCV infected patients (percentage of cases in parenthesis). Black circles represent terminal nodes with high probability to develop hepatocellular carcinoma (HCC) (ratio ≥ 70%); gray circles represent terminal nodes with intermediate probability to develop HCC (30 ≤ ratio < 70%); white circles represent terminal nodes with low probability to develop HCC (ratio < 30%). Odds ratios (OR) and 95%CI were calculated for each group in respect to the reference group (lower HCC risk) through logistic regression model, adjusted for sex, age and viral status. ¹Number of alleles carried by the patient. CART: Classification and regression tree; HCC: Hepatocellular carcinoma; HBV: Hepatitis B viral; HCV: Hepatitis C viral.