Maytenus erythroxylon Reissek (Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms

Figure 1 Effect of oral administration of EtOHE-Me and loperamide on gastric emptying of mice. Data are presented as mean ± SD. ^aP < 0.05, ^bP < 0.001, vs NaCl 0.9% group. EtOHE-Me: Ethanol extract of Maytenus erythroxylon.

Figure 2 Effect of oral administration of EtOHE-Me and loperamide on intestinal transit of mice. Data are presented as mean ± SD. ^aP < 0.001 vs NaCl 0.9% group. EtOHE-Me: Ethanol extract of Maytenus erythroxylon.

Figure 3 Effect of oral administration of Ethanol extract of Maytenus erythroxylon Glibenclamide, L-N^G-nitroarginine methyl ester, propranolol and yohimbine on intestinal transit of mice. Data are presented as mean ± standard deviation. ^aP < 0.05 vs NaCl 0.9% group. EtOHE-Me: Ethanol extract of Maytenus erythroxylon; L-NAME: L-N^G-nitroarginine methyl ester.

Figure 4 Effect of oral administration of Ethanol extract of Maytenus erythroxylon and loperamide in castor oil-induced enteropooling in mice. Data are presented as mean ± SD. ^aP < 0.001 vs NaCl 0.9% group. EtOHE-Me: Ethanol extract of Maytenus erythroxylon.