Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer

Figure 1 Representative immunohistochemistry results of pleiotrophin (× 400) and N-syndecan (× 200). Paraffin sections were immunostained as described in Methods. A: Tumor tissue showing moderate pleiotrophin (PTN) expression; B: Tumor tissue showing intense PTN expression; C: Negative N-syndecan expression in perineurium of nerves of pancreatic cancer; D: Positive N-syndecan expression in the perineurium of nerves of pancreatic cancer.

Figure 2 Kaplan-Meier survival curves in pancreatic cancer based on pleiotrophin expression. PTN: Pleiotrophin.