SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging

Figure 1 Sagittal and coronal images of SPECT-computed tomography and the corresponding value of maximal signal colon wall intensity in a control (A) or 2,4,6-trinitrobenzene sulfonic acid (B) rat.

Figure 2 Validation of colitis. Colon weight: length ratio (A) colon cyclo-oxygenase-2 expression (B), inflammatory score (C) in rats with TNBS-induced colitis at day 2. Colitis was induced in rats by intrarectal injection of TNBS at day 0. ^aP < 0.05, ^bP < 0.01 vs control rats respectively.

Figure 3 SPECT-computed tomography parameters. Maximal thickness (A), pixel max (B) and colon diameter (C) in rats with TNBS-induced colitis at day 2. Colitis was induced in rats by intrarectal injection of TNBS at day 0.

Figure 4 Association between SPECT-computed tomography parameters with inflammatory markers in rats with 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Colitis was induced in rats by intrarectal injection of TNBS at day 0. SPECT- computed tomography was performed at day 2. A: Simple linear regression between maximal thickness and colon cycloxygenase-2 expression; B: Simple linear regression between pixel max and colon weight:length ratio; C: Simple linear regression between colon diameter and colon cycloxygenase-2 expression; D: Maximal thickness according to histological inflammation score.