Artificial liver support in pigs with acetaminophen-induced acute liver failure

Figure 1 Survival curves of the porcine models in the treatment and control groups.

Figure 2 Hepatocyte swelling, nuclear fragmentation, and dissolution. Electron microscopy, × 10800.

Figure 3 Changes in serum biochemical parameters before (baseline) and 20 h after administration of acetaminophen. Serum AST, Tbil, NH3, and Cr levels were increased, while Alb levels showed a decrease. Prothrombin time was prolonged. About 28 h after administration of acetaminophen, AST, Tbil, NH3 and Cr remained elevated while Alb remained decreased. But in the bioartificial liver system group, AST, Tbil, NH3 and Cr decreased significantly in comparison with the control group. ^aP < 0.05 vs control group.