Hepatitis E virus: Western Cape, South Africa

Figure 1 Overall seroprevalence curve and individual seroprevalence curves in 3 racial groups in Western Cape, South Africa. Anti-HEV IgG seroprevalence by age in Western Cape, South Africa.

Figure 2 A maximum likelihood tree constructed in MEGA6 from an alignment of a 301nt fragment of ORF2. Bootstrap support above 60% is shown. Our patient’s viral sequence, GenBank accession KT833800, is highlighted in red. The tree is rooted on the HEV reference sequence (genotype 1). Sequences for comparison have names starting with genotype, followed by Genbank accession number, followed by country ISO 3166-1 abbreviation (CA: Canada; ES: Spain; GB: United Kingdom; JP: Japan; NL: The Netherlands; TW: Taiwan; US: United States of America; ZA: South Africa), and ending in source (D: Deer; H: Human; P: Pig). The patient’s viral sequence clusters within genotype 3 (with subgenotype 3e), in keeping with other viruses recently described in South Africa[11,12,24].