Infliximab does not increase colonic cancer risk associated to murine chronic colitis

Figure 1 Effect of Infliximab on dextran sodium sulphate induced chronic colitis in mice. A: Disease activity index (DAI) in infliximab (IFX) treated animals compared with controls (CT); B: Body weight variation in IFX treated animals compared with CT; C: Colon length at sacrifice in IFX treated mice compared with CT; D: Histology assessment in IFX treated mice compared with CT. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs controls.

Figure 2 Effect of Infliximab on colonic cancer lesions associated to chronic colitis in mice. A: Macroscopic lesion number in Infliximab treated mice compared with controls; B: Microscopic colon lesions classified as carcinoma (K), high grade-dysplasia adenoma (HGA) and low grade-dysplasia adenoma (LGA); C: Macroscopic colon lesions (Infliximab treated on the left and controls on the right); D: Histological photos of carcinoma (K), high grade-dysplasia adenoma (HGA) and low grade-dysplasia adenoma (LGA).

Figure 3 Effect of Infliximab on proliferation and vitality of colonic cancer cell line CT26: MTT assay. A: MTT performed without cell pre-treatment; B: MTT performed following 24 h cell pre-incubation with TNFα.