Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis

Figure 1 Changes in gastrointestinal symptom scores in each group. ^aP < 0.05, ^bP < 0.01 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Figure 2 Comparison of 5-HT and 5-HIAA concentrations in each group. ^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Figure 3 TPH1 protein expression in the colonic mucosa of patients from each group. ^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Figure 4 5-HT3R, 4R, and 7R receptor mRNA expression in each group. ^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.

Figure 5 Comparison of serotonin transporter protein gray values. ^aP < 0.05 vs normal. UC: Ulcerative colitis; IBS-D: Diarrhea-predominant irritable bowel syndrome.