Microscopic enteritis: Bucharest consensus

Figure 1 Legends for micrographs. A: Microscopic enteritis (ME), normal villi with pathological increase of T lymphocytes, HE × 10; B: ME with immunohistochemistry for CD3 × 10; C: ME; evident pathological number of T lymphocytes in the superficial epithelium of villi. CD3 immunohistochemistry × 40; D: This diagram is representative of the phases of ME, in addition to the Marsh I ("infiltrated") and Marsh II ("infiltrated-hyperplastic") lesions, it is important to note that a histologically normal-appearing mucosa is a part of the ME spectrum, and that its underlying pathological connotations should therefore not be overlooked nor ignored.

Figure 2 Algorithm for diagnosis the underlying condition behind microscopic enteritis. HLA: Human leucocyte antigen; EMA: Endomysial antibodies; tTGA: Tissue transglutaminase antibodies; AgA: Antigliadin antibodies; NCGS: Non coeliac gluten sensitivity; NSAIDs: Non-steroidal anti-inflammatory drugs; IBD: Inflammatory bowel disease; AE: Autoimmune enteropathy; EGE: Eosinophilic gastroenteritis; CVID: Common variable immunodeficiency; CGE: Collageneous gastroenteritis; MVID: Microvillous inclusion disease; H. pylori: Helicobacter pylori.