High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus

Figure 1 Endoscopic view of the esophagus showing granular changes of the inner surface as well as whitish discoloration.

Figure 2 Initial forceps biopsy results. A: Tangential section through the esophageal epithelium. Numerous atypical cells adjacent to the subepithelial papillae, overlying squamous epithelium without atypia. Hematoxylin and eosin stain; original magnification × 10; B: High-magnification of tumor cells with highly atypical nuclei, loss of cell cohesion, and either polygonal or spindle-cell shapes.

Figure 3 Esophageal squamous epithelium showing atypical cells with accumulation of the p53-protein, restricted to the basal portion of the epithelium.