Comparison of selected inflammation-based prognostic markers in relapsed or refractory metastatic colorectal cancer patients

Figure 1 Flow chart of patients’ dispositions.

Figure 2 Overall survival of enrolled patients according to the systemic inflammation markers. Overall survival of total enrolled patients (A), overall survival according to modified Glasgow prognostic score (B), neutrophil lymphocyte ratio (C), platelet lymphocyte ratio (D), prognostic nutritional index (E), and lymphocyte monocyte ratio (F).

Figure 3 Receiver operating characteristic curves for lymphocyte monocyte ratio (A), prognostic nutritional index (B), hemoglobin (C), neutrophil% (D), lymphocyte% (E), monocyte% (F), absolute neutrophil count (G), absolute lymphocyte count (H), and absolute monocyte count (I) of total enrolled patients. Lymphocyte to monocyte ratio: sensitivity 68.0%, specificity 62.5%, area under the ROC curve (AUC) 0.647, P value 0.0048, cut-off 3.4; Prognostic nutritional index: sensitivity 34.0%, specificity 95.8%, AUC 0.559, P value 0.2557, cut-off 45.3; Hemoglobin: sensitivity 58.8%, specificity 79.2%, AUC 0.668, P value 0.0077, cut-off 12.1g/dL; Neutrophil%: sensitivity 51.6%, specificity 75.0%, AUC 0.578, P value 0.1748, cut-off 68.2%. Lymphocyte%: sensitivity 66.7%, specificity 62.5%, AUC 0.620, P value 0.0325, cut-off 24.3%. Monocyte%: sensitivity 69.3%, specificity 50.0%, AUC 0.583, P value 0.1707, cut-off 6.6%; Absolute neutrophil count: sensitivity 44.4%, specificity 79.2%, AUC 0.614, P value 0.0506, cut-off 4505.7; Absolute lymphocyte count: sensitivity 71.2%, specificity 41.7%, AUC 0.516, P value 0.8047, cut-off 1651.3; Absolute monocyte count: sensitivity 56.9%, specificity 70.8%, AUC 0.641, P value 0.0239, cut-off 460.8.