Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma

Figure 1 Schematic representation of various treatment strategies for hepatocellular carcinoma at different stages according to the Barcelona Clinic Liver Cancer algorithm. RFA: Radiofrequency ablation, PEI: Percutaneous ethanol injection; TACE: Trans catheter arterial chemoembolization.

Figure 2 Different methods of targeted delivery of nanoparticles by passive or active mechanism. EPR: Enhanced permeation and retention.

Figure 3 Schematic representation of the biotinylated cyclic Arg-Gly-Asp nanoparticles loaded with doxorubicin. PEG: Polyethylene glycol; RGD: Arg-Gly-Asp.