Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

Figure 1 Changes of shear-wave velocity values after interferon plus ribavirin therapy. The shear-wave velocity (Vs) values in the figure were expressed as overall medians. A: In SVR patients, Vs values were significantly lower at EOT [1.19 (1.07-1.36)] than at pretreatment [1.28 (1.11-1.51)] (P = 0.0004) in 39 patients in whom Vs values were measured at both points. Vs values were significantly lower at 1 year after treatment [1.10 (1.00-1.23)] than at pretreatment [1.27 (1.11-1.46)] (P = 0.0001) in 33 patients in whom Vs values were measured at both points. Vs values were significantly lower at 2 years after treatment [1.05 (0.96-1.16)] than at pretreatment [1.25 (0.97-1.47)] (P < 0.0001) in 22 patients in whom Vs values were measured at both points. Vs values were significantly lower at 1 year after treatment [1.07 (0.96-1.17)] than at EOT [1.20 (1.05-1.33)] (P = 0.0022) in 20 patients in whom Vs values were measured at both points; B: In patients who relapsed, Vs values did not significantly differ among pretreatment, EOT, 1 year, and 2 years after treatment; C: In patients with NVR, Vs values were significantly higher at 1 year after treatment [1.72 (1.43-2.00)] than at EOT [1.56 (1.25-1.75)] (P = 0.0313) in 11 patients in whom Vs values were measured at both points. Vs values were significantly higher at 2 years after treatment [1.58 (1.40-1.66)] than at EOT [1.37(1.23-1.57)] (P = 0.0469) in 7 patients in whom Vs was measured in both points.