Giant liposarcoma of the esophagus: A case report

Figure 1 Radiological imaging of the esophageal liposarcoma. A-C: Computed tomographic scan; D: Barium swallow.

Figure 2 Endoscopic results of the esophageal liposarcoma. A large submucosal lesion or an extrinsic compression encompassing the esophageal lumen at 20 cm to 35 cm from the incisor teeth was revealed through a diagnostic flexible endoscopy. The remaining lower region of the esophagus and the gastro-esophageal junction was normal in appearance.

Figure 3 Surgical specimen of the esophageal liposarcoma. Normal esophageal mucosa is shown covering the surface of the tumor. A yellow lobulated transmural mass invading the esophageal wall is visible at one surgical margin of the specimen.

Figure 4 Histological analysis reveals a well-differentiated myxoid esophageal liposarcoma with a dedifferentiated component. Hematoxylin and eosin stain of paraffin-embedded sections highlighting histological features of the case. A: Myxoid tumor cells located just under normal squamous cell epithelia (magnification × 100); B: Spindle tumor cells (magnification × 200); C: Dedifferentiated component of the liposarcoma (magnification × 100); D: Lipoblast cells (magnification × 200).

Figure 5 CDK4 and MDM2 expression in the tumor as determined by immunohistochemistry. Paraffin-embedded sections of the primary tumor are stained for A: CDK4 in a well-differentiated area (magnification × 200); B: CDK4 expression in a dedifferentiated area (magnification × 200); C: MDM2 in a well-differentiated area (magnification × 200); and D: MDM2 expression in a dedifferentiated area (magnification × 200).