Hepatoprotective effect of Geranium schiedeanum against ethanol toxicity during liver regeneration

Figure 1 Chemical structure of geraniin (A) and of acetonyl-geraniin (B).

Figure 2 Aspartate aminotransferase activity in serum (upper panel) and in the liver (lower panel) in distinct study groups. Values are expressed as mean ± SE in each experimental group; n = 5-6). ^aP < 0.05 vs sham group; ^cP < 0.05 vs PH group; ^eP < 0.05 vs PH-Gs-EtOH group. PH: Partial hepatectomy; EtOH: Ethanol; Gs: Geranium schiedeanum.

Figure 3 Alanine aminotransferase enzymatic activity in serum (upper panel) and in the liver (lower panel) in distinct study groups. Values are expressed as the mean ± SE (n = 5-6). ^aP < 0.05 vs sham group; ^cP < 0.05 vs PH group; ^eP < 0.05 vs PH-Gs-EtOH group. PH: Partial hepatectomy; EtOH: Ethanol; Gs: Geranium schiedeanum.

Figure 4 Thiobarbituric acid reactive substances concentration in serum (upper panel) and in the liver (lower panel) during liver regeneration and intoxication with ethanol. Values are expressed as the mean ± SE (n = 5-6). ^aP < 0.05 vs sham group; ^cP < 0.05 vs PH group; ^eP < 0.05 vs PH-Gs-EtOH group. PH: Partial hepatectomy; EtOH: Ethanol; Gs: Geranium schiedeanum.

Figure 5 Effect of the Geranium schiedeanum extract on the concentration of the total antioxidant status in serum (upper panel) as well as the total antioxidant capacity in liver (lower panel) on liver regeneration and intoxication with ethanol. Values are expressed as the mean ± SE (n = 5-6). ^aP < 0.05 vs sham group; ^cP < 0.05 vs PH group; ^eP < 0.05 vs PH-Gs-EtOH group. PH: Partial hepatectomy; EtOH: Ethanol; Gs: Geranium schiedeanum.