Primary biliary cirrhosis: Clinical and laboratory criteria for its diagnosis

Figure 1 Scheme of mechanism of development of pruritus in primary biliary cirrhosis.

Figure 2 Xanthelasmas on both eye lids in a patient with primary biliary cirrhosis.

Figure 3 The scheme of the development of osteoporosis in primary biliary cirrhosis.

Figure 4 Stage I primary biliary cirrhosis. Inflammatory infiltrate consisting of mononuclear cells around the bile duct (BD). Hematoxylin eosin staining, magnification × 125.

Figure 5 Stages II-III primary biliary cirrhosis. A: Wide septa formed by proliferating ductuli. Lymphocytic infiltration. Hematoxylin eosin staining, magnification × 200. B: Hyaline inclusions. Swelling and hepatocellular injury due to the damaging effect of bile acids. van Gieson's, magnification × 200.

Figure 6 Stages IV primary biliary cirrhosis. Cirrhotic transformation. Silver impregnation method for Gomory, magnification × 200.

Figure 7 Schematically summarizes the clinical, biochemical, immunological, and morphological signs of primary biliary cirrhosis.