Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis

Figure 1 Size distribution and overlap analysis of copy number variable regions and associated genes. A: Each chromosome wide copy number variation (CNV) size distribution across samples from ulcerative colitis (UC) to colitis associated colorectal cancer (CAC); B: Histogram representation of distribution of CNV sizes on all 4 samples analyzed by CNV association microarrays; C: Venn diagram showing the number of unique and common genes in different groups from UC to CAC. D: CIRCOS plot highlighting progressive CNV association analysis during UC progression to CRC using 2×105 k arrays (UC-LR, UC-HR, UC-PM and UC-CRC or CAC: in the order from outer circle to inner circle). LR: Low risk; HR: High risk; PM: Premalignant.

Figure 2 Summary results of gene ontology analysis carried out on 2 × 105 k data from different ulcerative colitis sample groups. X-axis: Molecular function and Y-axis: Number of genes involved. UC: Ulcerative colitis; CAC: Colitis-associated colorectal cancer; LR: Low risk; HR: High risk; PM: Premalignant.