Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: A meta-analysis

Figure 1 Meta-analysis. A: Symptom response in 5-hydroxytryptamine (5-HT) and GABA-B receptor therapies; B: Symptom response in the 5-HT receptor agonist group; C: Symptom response in the GABA-B receptor agonist group; D: Symptom score change (FSSG) in the two therapies; E: Endoscopic response in 5-HT and GABA-B receptor therapies; F: Wave amplitude in 5-HT and GABA-B receptor therapies; G: Wave duration in 5-HT and GABA-B receptor therapies; H: Adverse events proportion in 5-HT and GABA-B therapies; I: Adverse events in 5-HT agonist group; J: Adverse events in GABA-B receptor agonist group.

Figure 2 Funnel plots for publication bias in meta-analysis. A: No publication bias was detected in symptom response (Egger’s test P = 0.333; Begg’s test P = 0.721); B: Adverse event proportion (Egger’s test P = 0.246; Begg’s test P = 0.452).