Targeting cell death signaling in colorectal cancer: Current strategies and future perspectives

Figure 1 Apoptosis signaling and cell death relevant drugs. Cell death based cancer therapy can be approached by targeting proteins in the extrinsic or intrinsic pathway. Relevant agents, currently under clinical investigation, are listed and placed to their targets. APAF1: Apoptotic protease activating factor-1; CytC: Cytochrome C; IAP: Inhibitors of apoptosis; tBID: Truncated BID; FADD: Fas-associated protein with death domain; TNF: Tumor necrosis factor; TRAIL: Tumor necrosis factor related apoptosis-inducing ligand.