Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Figure 1 Steatosis in nonalcoholic fatty liver disease. Macrovesicular steatosis, predominantly distributed in zone 3, is observed (Masson trichrome staining).

Figure 2 Lobular inflammation in nonalcoholic steatohepatitis. Necroinflammatory foci (arrows) are scattered in the hepatic lobule (hematoxylin and eosin staining).

Figure 3 Ballooning and Mallory-Denk bodies in nonalcoholic steatohepatitis. Ballooned hepatocytes are recognized as swollen hepatocytes with rarefied cytoplasm (black arrows). Mallory-Denk bodies are eosinophilic irregular-shaped aggregates in the cytoplasm of hepatocytes (white arrow) (hematoxylin and eosin staining).

Figure 4 Fibrosis in nonalcoholic steatohepatitis. The characteristic pattern of fibrosis in nonalcoholic steatohepatitis is perisinusoidal/pericellular (chicken wire) fibrosis, which usually begins in zone 3 (reticulin staining).

Figure 5 Histological appearance of alcoholic steatohepatitis. Canalicular cholestasis (black arrow), Mallory-Denk bodies (white arrows), and acute inflammation in the portal tract are observed (hematoxylin and eosin staining).

Figure 6 Histological appearance of steatohepatitic hepatocellular carcinoma. Large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies (arrows), inflammation, and fibrosis are observed in tumor tissue (hematoxylin and eosin staining).