Rho/ROCK signaling in motility and metastasis of gastric cancer

Figure 1 Presents an overview of the Rho/Rho-associated protein kinases signaling pathway. MYPT1: Myosin phosphatase 1; MLC: Myosin light chain; ERM: Ezrin/radixin/moesin; ROCK: Rho-associated protein kinases; LIMK: LIM kinase.

Figure 2 Reorganization of the actin cytoskeleton is involved in these processes which is regulated by Rho GTPases.

Figure 3 Cancer cells display two different modes of cell motility: epithelial-mesenchymal transition and amoeboid transition. A: cells move in groups through the extracellular matrix and maintain cell–cell adhesions in sheet-like structures; B: Mesenchymal movement requires degradation of the extracellular matrix (ECM), similar to collective movement; C: Cells with amoeboid movement migrate in an integrin-independent manner.