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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 14, 2014; 20(38): 13741-13755
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13741
Figure 1
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Figure 1 Human epidermal growth factor receptor 2 signaling pathways. HER: Human epidermal growth factor receptor; BAD: Bcl-2-associated death promotor protein; Grb2: Growth factor receptor-bound protein 2; MAPK: Mitogen-activated protein kinase; MEK: Mitogen-activated protein kinase kinase 1; NF-κB: Nuclear factor κB; PI3K: Phospohoinositide 3-kinase; PKC: Protein kinase C; PLC-γ: Phospholipase C gamma 1; SOS: Son of sevenless; mTOR: Mammalian target of rapamycin; RAS: Rat sarcoma viral oncogene; RAF: Rapidly accelerated fibrosarcoma.
Figure 2
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Figure 2 Angiogenic signaling pathways. AKT: Protein kinase B.
Figure 3
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Figure 3 Epidermal growth factors signaling pathways. Activation of EGFR leads to downstream signaling pathways that ultimately drive tumour proliferation or impair apoptosis. JAK: Janus kinase; STAT: Signal transduction and activator of transcrption; ERK: Extracellular signal-regulated kinase; PI3K: Phospohoinositide 3-kinase; PKC: Protein kinase C; PLC: Phospholipase C; SOS: Son of sevenless; mTOR: Mammalian target of rapamycin; RAS: Rat sarcoma viral oncogene; RAF: Rapidly accelerated fibrosarcoma; EGFR: Epidermal growth factor receptor.