Esophageal squamous cell carcinoma with dural and bone marrow metastases

Figure 1 Magnetic resonance imaging study demonstrates diffuse dural thickening and enhancement in bilateral pachymeninges (arrowhead), and an enhancing mass in the right skull (arrow).

Figure 2 Histologic and immunohistochemical pictures. A: Histologic picture shows clusters of epithelial-like cells, with eosinophilic cytoplasm and hyperchromatic nuclei. Some nuclei had prominent nucleoli with a high nuclear-to-cytoplasmic ratio. (hematoxylin and eosin staining, original magnification × 100); B: Immunohistochemical picture reveals positivity for high molecular weight (HMW) cytokeratin (original magnification × 200).