Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: New clues for the pathogenesis of H. pylori-related gastric inflammation

doi:10.3748/wjg.v20.i3.639

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Jan 21, 2014 (publication date) through Dec 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2014; 20(3): 639-646
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.639

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Figure 1 Main functions of ghrelin in the human body. INF: Interferon; IL: Interleukin; PGE₂: Prostaglandin E2; Th1: T helper 1; APC: Antigen presenting cell.

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Figure 2 Downregulation of ghrelin expression in the stomach during Helicobacter pylori infection. Epithelial damage and gastritis induced by Helicobacter pylori determine a diminished expression of ghrelin which, in turn, sustains the ongoing T helper (Th) 1 cells response. Down regulation of ghrelin is also followed by a reduced release of Prostaglandin E2 (PGE₂) and interleukin (IL)-10 which, together with pro-inflammatory factors as IL-1β, contribute to the detrimental immune response and damage in the stomach. APC: Antigen presenting cell.

Citation: Paoluzi OA, Blanco DVG, Caruso R, Monteleone I, Monteleone G, Pallone F. Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: New clues for the pathogenesis of H. pylori-related gastric inflammation. World J Gastroenterol 2014; 20(3): 639-646
URL: https://www.wjgnet.com/1007-9327/full/v20/i3/639.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i3.639