Update on the prevention of local recurrence and peritoneal metastases in patients with colorectal cancer

Figure 1 Local-regional treatment failure with colorectal cancer resection may present as local recurrence and/or peritoneal metastases. Free cancer cells or tiny nodules disseminated from the primary cancer may implant and grow at high density at the resection site as a local recurrence. Low density cancer implants at a distance will become peritoneal metastases.

Figure 2 Two ways to enter the proactive management clinical pathway. HIPEC: Hyperthermic perioperative chemotherapy; FOLFOX: Folinic acid, 5-fluorouracil, and oxaliplatin.

Figure 3 Hazard ratios and multilevel confidence intervals for prognostic factors of survival in patients with peritoneal carcinomatosis of colorectal origin treated by CRS and hyperthermic perioperative chemotherapy[7]. HR: Hazard ratio.