Molecular identification of hepatitis B virus genotypes/subgenotypes: Revised classification hurdles and updated resolutions

doi:10.3748/wjg.v20.i23.7152

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2014; 20(23): 7152-7168
Published online Jun 21, 2014. doi: 10.3748/wjg.v20.i23.7152

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Figure 1 Neighbour-joining phylogenetic tree was conducted based on hepatitis B virus full-length genomes of all proposed genotypes and subgenotypes before (A) and after (B) reclassification. HBV genome sequence that used are listed below: JN182318: A1; HE576989: A2; AB194951: A3; AY934764: A4; FJ692613: A5; GQ331047: A6; FN545833: A7; AB642091: B1; FJ899779: B2; GQ924617: B3; GQ924626: B4; GQ924640: B5; JN792893: B6; GQ358137: B7; GQ358147: B8; GQ358149: B9; AB697490: C1; GQ358158: C2; DQ089801: C3; HM011493: C4; EU410080: C5; EU670263: C6; GU721029: C7; AP011106: C8; AP011108: C9; AB540583: C10; AB554019: C11; AB554025: C12; AB644280: C13; AB644284: C14; AB644286: C15; AB644287: C16; GU456636: D1; GQ477452: D2; EU594434: D3; GQ922003: D4; GQ205377: D5; KF170740: D6; FJ904442: D7; FN594770: D8; JN664942: D9; FN594748: E; FJ709464: F1b; DQ899146: F2b; AY090459: F1a; DQ899142: F2a; AB036920: F3; AF223965: F4; GU563556: G; AB516393: H; FJ023659: I1; FJ023664: I2 ; AB486012: J and AY226578: Woolly monkey as an out-group. HBV: Hepatitis B virus.

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Figure 2 The time line of identification and designation of hepatitis B virus subgenotypes.

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Figure 3 Geographical distribution of hepatitis B virus genotypes and subgenotypes in different regions of the world. Yellow arrows illustrate the directions of HBV subgenotype dispersal through immigration from highly and intermediate endemic countries to low HBV endemic areas (map of hepatitis B surface antigen (HBsAg) prevalence adapted from the website of the WHO). HBV: Hepatitis B virus; WHO: World Health Organization.

Citation: Pourkarim MR, Amini-Bavil-Olyaee S, Kurbanov F, Van Ranst M, Tacke F. Molecular identification of hepatitis B virus genotypes/subgenotypes: Revised classification hurdles and updated resolutions. World J Gastroenterol 2014; 20(23): 7152-7168
URL: https://www.wjgnet.com/1007-9327/full/v20/i23/7152.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i23.7152