Prediction of Crohn’s disease aggression through NOD2/CARD15 gene sequencing in an Australian cohort

Figure 1 Pathogenic mutation within the nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene. A: Physical map of the exon-intron organization of the nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) gene and the approximate positioning of the mutations within the gene; B: Structural domain of the NOD2/CARD15 gene. Like the other members of the NOD/leucine rich repeat domain (LRR) protein family, NOD2/CARD15 consists of three distinct functional domains: CARD, a centrally located NOD and a LRR.

Figure 2 Time between Crohn’s disease diagnosis and initial surgery according to nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 status.