Expression of monocyte chemotactic protein-1/CCL2 in gastric cancer and its relationship with tumor hypoxia

Figure 1 The expression patterns of CCL2 and hypoxia-inducible factor 1α were detected in consecutive human gastric cancer tissues sections. A: Expression pattern of hypoxia-inducible factor 1 alpha (HIF-1α) in human gastric cancer tissues (100 ×); B: Expression pattern of CCL2 in the human gastric cancer tissues (400 ×). The spatial distribution of HIF-1α expression was consistent with that of CCL2 in tumor sections. (A-1 vs B-1, A-2 vs B-2).

Figure 2 Immunohistochemical detection of the expression pattern of CCL2 in human gastric cancer tissue. A: Expression pattern of CCL2 in gastric cancer (100 ×); C, E: Positive staining for CCL2; D, E: Expression pattern of CCL2 in gastric cancer (400 ×); The images in D and E are the amplified sections corresponding to B and C. B, D: Negative staining for CCL2.

Figure 3 Relationship between the expression of CCL2 and overall survival time in gastric cancer patients. Patients with high CCL2 expression had a poor overall survival [50.6 mo (95%CI: 44.44-56.93) vs 64.6 mo (95%CI: 60.27-68.94), P = 0.013].