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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3475-3484
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3475
Figure 1
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Figure 1 Metabolic pathway of azathioprine/mercaptopurine metabolism. AZA: Azathioprine; MP: Mercaptopurine; TPMT: Thiopurine methyltransferase; XO: Xanthine oxidase; IMPDH: Inosine-5-monophosphate dehydrogenase; GMPS: Guanidine- 5-monophosphate synthetase; 6-TA: 6-Thiouric acid; 6-MMP: 6-Methyl- mercaptopurine; 6-TIMP, 6-Thioinosine monophosphate; 6-MeTIMP: 6-Methylthioinosine monophosphate; 6-MeTITP: 6-Methyl thioinosine triphosphate pyrophosphate; 6-TITP: 6-Thioinosine triphos- phate pyrophosphate; TXMP: Thioxanthosine monophosphate; 6-TGN: 6-Thioguanine nucleotides; 6-TGMP: 6-Thioguanine monophosphate; 6-TGDP: 6-Thioguanine diphosphate; 6-TGTP: 6-Thioguanine triphosphate.
Figure 2
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Figure 2 Algorithm with recommendation on how to manage patients that fail therapy with Azathioprine/Mercaptopurine. AZA: Azathioprine; MP: Mercaptopurine; 6-TGN: 6-Thioguanine nucleotides; 6-MMP: 6-Methyl-mercaptopurine.
Figure 3
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Figure 3 Variables associated with Anti-tumor necrosis factor levels. TNF: Tumor necrosis factor.
Figure 4
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Figure 4 Approaches to patients on infliximab in the setting of lose of response. ATI: Anti-infliximab antibody; IFX: Infliximab; TNF: Tumor necrosis factor.