Midkine promotes perineural invasion in human pancreatic cancer

Figure 1 Representative immunohistochemistry results of midkine and syndecan-3 (× 200). Paraffin sections were immunostained as described in Materials and Methods. A: Normal tissue showing negative midkine (MK) expression; B: Tumor tissue showing negative MK expression; C: Tumor tissue showing moderate MK expression; D: Tumor tissue showing intense MK expression; E: Negative syndecan-3 expression in cancer; F: Positive syndecan-3 expression in the perineurium of nerves in pancreatic cancer.

Figure 2 Kaplan-Meier analysis of overall postoperative survival curves in pancreatic cancer cases according to their immunohistochemical staining for midkine (A) and syndecan-3 (B).