Intestinal stem cell marker LGR5 expression during gastric carcinogenesis

Figure 1 Immunodetected differential LGR5 expression in gastric tissues, following progression of tumorigenesis, and in distant metastases. Representative samples are shown from leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)^- (A) and LGR5⁺ (B) normal gastric normal tissues, LGR5^- (C) and LGR5⁺ (D-F) gastric cancer (GC) tissues with weak, moderate and strong expression, LGR5⁺ gastric intestinal metaplasia and dysplasia tissues (G, H), and LGR5⁺ lymph node and liver metastases (I, J). A, C-J: Magnification: × 200; B: Magnification: × 100.