Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

Figure 1 Flowchart of study participants recruited from the two-step colorectal cancer screening program. O: Other; A: Adenoma; AA: Advanced adenoma; C: Cancer.

Figure 2 Cancer stage difference between the colorectal cancer screening program and cancer registry database. The cancer stage (X-axis) and proportion (Y-axis) of screening-detected cancers (CS) and the hospital cancer registry (CR) database. The stage migration was calculated as the difference in cancer proportions between the two databases (CS-CR).

Figure 3 Age, gender, and fecal immunochemical test concentration in association with histological grade of colorectal tumor. A: Age; B: gender; C: FIT. The differences in age, gender, and FIT concentrations (Y-axis) in the different histological groups (X-axis). (Kruskal-Wallis test, all P < 0.001). FIT: fecal immunochemical test; O: Other; A: Adenoma; AA: Advanced adenoma; C: Cancer.

Figure 4 Fecal immunochemical test concentration in the prediction of colorectal neoplasia: linear regression analysis. The association between FIT concentration with log(2) transformation (X-axis) and PPV (Y-axis). (all R² > 0.95, P < 0.001). FIT: Fecal immunochemical test; O: Other; A: Adenoma; AA: Advanced adenoma; C: Cancer; PPV: Positive predictive value.