Extravascular use of drug-eluting beads: A promising approach in compartment-based tumor therapy

Figure 1 Peritoneal metastasis. A: Beads accumulate in the mesentery of the small bowel (arrors). Animals show a complete tumor remission; B: Control animal with disseminated peritoneal carcinomatosis induced by EGFP-C-26 cells.

Figure 2 Doxorubicin-eluting beads. A: HE-stained, magnification × 50: A layer of fibrin (between arrows) immobilizing the doxorubicin-loaded DC beads (DOXDEB™) on the livers surface; B: HE-stained, magnification × 100: DOXDEB™ in layer of fibrin and surrounded by lymphocytes immobilizing it on mesenteric connective tissue.

Figure 3 Chemical peritonitis. Autopsy of an animal 28 d after installation of ip doxorubicin-loaded drug-eluting beads: Situs with greater omentum and intestinal loops with fibrinous adhesions, amber-colored ascitic fluid.