Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility

Figure 1 Dysphagia score in patients with irritable bowel syndrome, systemic lupus erythematosus and systemic sclerosis. All groups showed similar abnormal dysphagia scores. The mean value of dysphagia score was in IBS group 7.3, in SLE group 6.73 and in SSc group 7.56. IBS: Irritable bowel syndrome; SLE: Systemic lupus erythematosus; SSc: Systemic sclerosis.

Figure 2 Amplitudes of the peristaltic waves throughout esophagus. The mean value of amplitudes in patients with SSc was significant lower comparing to subjects with SLE and IBS in the middle (B) and distal (A) esophagus (^bP < 0.01 vs SSc). In the proximal part (C) IBS patients showed higher peristaltic amplitudes in comparison to the other groups (^cP = 0.05 vs SLE). Normal values as previously described. IBS: Irritable bowel syndrome; SLE: Systemic lupus erythematosus; SSc: Systemic sclerosis.

Figure 3 Comparative analysis of pathological manometric parameters in patients with irritable bowel syndrome, systemic lupus erythematosus and systemic sclerosis. 47.1% of SLE patients showed pressure of lower esophagus sphincter > 30 mmHg. 58.8% of SLE patients and 56.35% of SSc patients showed resting pressure of the upper esophagus sphincter < 40 mmHg. 23.5% of patients with SLE showed distal amplitudes > 160 mmHg and 29.4% middle amplitudes > 100 mmHg, whereas in the proximal part 45.5% of IBS patients had amplitudes > 60 mmHg. The majority of SSc patients showed as expected reduced peristaltic activity in the lower two thirds of esophagus. ^aP < 0.05 vs SLE and SSc; ^cP < 0.05 vs IBS and SSc; ^eP < 0.05, ^fP < 0.01 vs IBS and SLE. High PresLES: Pressure lower esophageal sphincter (LES) > 30 mmHg; Low PresUES: Pressure upper esophageal sphincter (UES) < 40 mmHg; High ampldist: Distal amplitude > 160 mmHg; High amplmidd: Middle amplitude > 100 mmHg; High amplprox: Proximal amplitude > 60 mmHg; Low ampldist: Distal amplitude < 50 mmHg; Low amplmidd: Middle amplitude < 40 mmHg; Low amplprox: Proximal amplitude < 30 mmHg; Low velocdist: Distal velocoty < 2 cm/s; Low velocmidd: Middle velocity < 2 cm/s; Low velocprox: Proximal velocity < 2 cm/s. IBS: Irritable bowel syndrome; SLE: Systemic lupus erythematosus; SSc: Systemic sclerosis.