A case of Cowden syndrome diagnosed from multiple gastric polyposis

Figure 1 Endoscopic examination. A: Esophageal acanthosis was noted; B: Multiple gastric polyps were noted on entire stomach; C: Several polyps were observed at the rectum.

Figure 2 Microscopic examination (hematoxylin and eosin stain, × 100). A: Gastric polyp shows hyperplastic foveolar epithelium; B: Colon polyp exhibits dilated and branched crypts with slightly fibrotic stroma.

Figure 3 Thyroid masses. A: Multiple thyroid masses in thyroid ultrasonography; B: Postoperative thyroid pathology showed invasive follicular carcinoma (hematoxylin and eosin stain, × 12.5).

Figure 4 Sequencing result of the phosphatase and tensin homologue mutation. A heterozygous transition of C to A at nucleotide 633 in exon 6 (c.633C > A), making a stop codon (p.Cys211*).