Anti-tumor immunity, autophagy and chemotherapy

Figure 1 The process of macroautophagy and the types of autophagy (gray boxes).

Figure 2 The relation of autophagy and anticancer immunity. Similarly to autophagy-deficient tumor cells inhibition of autophagy results in decreased pericellular ATP secretion, and thus suppressing anticancer immunity. Pharmacologic inhibition of ATP degradation, however, increases ATP level in the microenvironment of tumor cells, and favours tumor cell immunogenicity.