Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment

Figure 1 Evolution of antiviral mutations in hepatitis B virus polymerase based on the clonal analysis of serial samples in patients. A: Patient 1; B: Patient 2; C: Patient 3; D: Patient 4. The boxes and capital letters denote the domains of the hepatitis B virus polymerase gene. ADV: Adefovir; LMV: Lamivudine; RT: Reverse transcriptase.

Figure 2 Clinical course and evolution of antiviral mutations in four patients. The arrows and numbers denote the time of the sampling of the serum and the sample number. ADV: Adefovir; ALT: Alanine aminotransferase; LMV: Lamivudine; TDF: Tenofovir; HBV: Hepatitis B virus.