Eosinophil associated genes in the inflammatory bowel disease 4 region: Correlation to inflammatory bowel disease revealed

Figure 1 Incidence curves, given as a mean of 5 consecutive years, are shown for the inflammatory bowel disease study cohort. Curves separated by gender and displaying the total inflammatory bowel disease cohort are included.

Figure 2 Prevalence of ECP434 genotypes in Crohn’s disease (black bars) and ulcerative colitis (grey bars). A: In females, age at disease diagnosis (ADD) > 45 years, a significant difference between Crohn’s disease (CD) and ulcerative colitis (UC) concerning ECP434 (P = 0.01, χ²) was observed; B: In men, ADD > 45 years a significant difference between CD and UC concerning ECP434 (P = 0.004) was observed. ECP: Eosinophil cationic protein.

Figure 3 Kaplan-Meier Curve of four groups haplotypes and EPX405, ECP562 genotypes. A: Kaplan-Meier Curve of four groups of haplotypes in male patients with ulcerative colitis (UC) (P = 0.0009); B: Kaplan-Meier Curve of four groups of haplotypes in female patients with Crohn’s disease (P = 0.003); C: Kaplan-Meier curve of the EPX405 genotype in men with UC (P = 0.007); D: Curve of the ECP434 genotype in men with UC (P = 0.002); E: Curve of the ECP562 genotype in males with UC (P = 0.01). Dotted line: GG genotype; Dashed line: GC genotype; Continuous line: CC genotype. ECP: Eosinophil cationic protein; EPX: Eosinophil protein X.

Figure 4 The box plots displays the association between the EPX405 genotypes and the intracellular content of eosinophil protein X and eosinophil cationic protein in eosinophils. The box plots display the distribution of the protein content within each class of genotype. A: Intracellular content of eosinophil protein X (EPX) (ANOVA P = 0.009). ^aP < 0.05 vs EPX405 GG genotype (Student-Newman-Keuls test); B: Intracellular content of eosinophil cationic protein (ANOVA P = 0.022). ^aP < 0.05 vs the EPX405 CC genotype (Student-Newman-Keuls test).

Figure 5 Distribution of allele frequencies, displaying the difference in patients with ulcerative colitis and dysplasia/cancer. Bars represent the allele frequency (%) of ECP434 (A) and ECP562 (B) single nucleotide polymorphism in patients with dysplasia/cancer (black bar), all patients with ulcerative colitis (grey bar), and healthy individuals (white bar). ECP: Eosinophil cationic protein.