Inhibition of gastric perception of mild distention by omeprazole in volunteers

Figure 1 Intragastric pressure by a barostat device at each score of upper abdominal feeling. The distention pressure required to induce a weak/vague feeling (score 1) in the upper abdomen increased from 3.0 ± 0.5 mmHg over the minimal distending pressure (MDP) at baseline to 4.6 ± 0.4 mmHg over the MDP after omeprazole, P = 0.019. The distention pressure to induce a weak but significant feeling (score 2) increased from 5.2 ± 0.7 mmHg to 7.8 ± 0.6 mmHg, P = 0.017. The n sizes for each data point are indicated on the graph.

Figure 2 Score of upper abdominal feeling during gastric distension by a barostat device. The mean scores at the intrabag pressures of minimal distending pressure (MDP) + 2 mmHg and + 4 mmHg were decreased from baseline after omeprazole: 1.1 ± 0.3 vs 0.3 ± 0.1, P = 0.028; and 2.0 ± 0.4 vs 0.8 ± 0.1, P = 0.0132, respectively. No significant changes were observed at pressures > MDP + 4 mmHg. The n sizes for each data point are indicated on the graph.