Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence

Figure 1 The immunohistochemistry for CD44 variant 6 and Pan-cytokeratin. A: The same tumor with “front-positive” membranous staining of CD44 variant 6 (CD44v6); B: Expanding growth pattern as shown with Pan-cytokeratin (Ck-Pan) staining; C: The same tumor with “front-negative” membranous staining of CD44v6; D: Infiltrating growth pattern as shown with Ck-Pan staining. Invasive front is indicated with arrows.

Figure 2 CD44 variant 6 related to disease-free and disease-specific survival in univariate analysis. Disease-free survival (A) and disease-specific survival (B) according to “front-positive” and “front-negative” membranous staining pattern of CD44 variant 6.