Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy

Figure 1 Flowchart for investigating effects of vagus nerve preservation and vagotomy on body weight and hormones such as peptide YY, ghrelin, leptin, insulin and growth hormone after total gastrectomy due to gastric cancer. AGC: Advanced gastric cancer; POD: Postoperative day; STG: Subtotal gastrectomy.

Figure 2 Correlations among vagus nerve preservation, body weight loss and peptide YY_3-36 increase. A: Vagus nerve preservation was correlated with body weight loss less than 10% [66.7% vs 0.0%, P = 0.011, odd ratio (OR) = 3.333, 95% confidence interval (95% CI) (1.293, 8.591)]; B: The vagus nerve preservation group showed significant correlation with peptide YY_3-36 level increases of less than 20% [55.6% vs 0.0%, P = 0.034, OR = 2.750, 95% CI (1.258, 6.010)]; C: Patients with body weight loss of less than 10% exhibited tight correlation with reduced elevation of peptide YY_3-36 level, typically less than 20% [83.3% vs 0.0%, P = 0.001, OR = 11.000, 95% CI (1.697, 71.282)]. PYY: Peptide YY.